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technologies > bile acid conjugates (bac) Bile Acid Conjugates (BAC)
BAC complexes are based on ionic interactions of carrier and drug molecule, which cross the intestinal wall together. However, once the complex reaches the enterocyte, the BAC portion is readily converted into endogenous components, thereby releasing the drug into the systemic circulation. Just as with the prodrug technology, an optimized BAC molecule is identified for each drug candidate, which provides the opportunity for unique formulation patents that are part of a product life cycle extension strategy.
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TSRL's bile acid carrier (BAC) technology relies on the same "shuttle" principle as the prodrug technology. By conjugating a drug candidate with poor intestinal permeability to a specific BAC, we enable the utilization of the ileal bile acid transporter to dramatically increase absorption. In addition, reliance on the bile acid transporter in the more distal portions of the intestine for absorption provide an elegant solution to circumvent the large abundance of gut metabolizing enzymes in the proximal intestine.