We have an active research program covering a wide range of topics related to oral and parenteral drug delivery. Listed below are selected references and patents describing work that has been done in our laboratories and those of our collaborators:
Jinno J. Oh D, Crison J, Amidon GL. Dissolution of Ionizable Water-Insoluble Drugs: The Combined Effect of pH and Surfactant. (2000) J. Pharm. Sci. 89 (2) 268-74.
Crison JR, Fleisher D. Preface: Advanced Drug Delivery Rev. 42(3): 163-4 (2000)
Loebenberg R, Vieira M, Amidon GL. Solubility as a limiting factor to drug absorption, In: Methods for Assessing Oral Drug Absorption, J.B> Dressman (Ed), Marcel Dekker, NY sub. Sept (1998)
Crison JR, Amidon GL. Predicting absorption of water insoluble compounds and other “difficult” molecules, Bull. Tech. Gattefosse, 90,21 (1997)
Crison JR, Weiner ND, Amidon GL. Dissolution Media for In Vitro Testing of Water-Insoluble Drugs: Effect of Surfactant purity and Electrolyte on In Vitro Dissolution of Carbamazepine in Aqueous Solutions of Sodium Lauryl Sulfate. (1997) J. Pharm. Sci. 86(3) 384-8.
Amidon GL, Choe SY, Vieira M, Oh DM. Solubility, intrinsic dissolution and solubilization: Influence on absorption, Scientific Foundations for Regulating drug Product Quality, Amidon GL, Robinson JR, Williams RL (Eds), AAPS Press, Alexandria, VA pp. 99-113 (1997)
Crison J, Shah V, Skelly J, Amidon GL. Drug Dissolution into Micellar Solutions: Development of a Convective Diffusion Model and Comparison to the Film Equilibrium Model with Application to Surfactant-Facilitated Dissolution of Carbamazepine. (1996) 85 (9) 1005-11.
Crison JR, Amidon GL. Expected variation in bioavailability for water insoluble drugs, in Bio-International 2, H.H. Blume and K.K. Midha (Eds) Medpharm Scientific Pub., (Stuttgart, Germany) pg. 301; (1995)
Crison JR, Amidon GL. Theoretical Approach to Controlled Delivery of Water Insoluble Drugs Based on Solubility and Surface Area. Proceed. Int’l. Symp. Control. Rel. Bioact. Mater. 21:2 (1994).
