We have an active research program covering a wide range of topics related to oral and parenteral drug delivery. Listed below are selected references and patents describing work that has been done in our laboratories and those of our collaborators:
Loebenberg R, Kim JS, Amidon GL. Pharmacokinetics of an Immediate Release, a Controlled Release and a Two Pulse Dosage Form in Dogs. (2005) Eur. Journal Pharm. Biopharm. 60 (1) 17-23.
Delaney B, Stevens LA, Schmelzer W, Haworth J, McCurry S, Hilfinger JM, Kim JS, Tsume Y, Amidon GL, Kritchevsky D., Oral absorption of phytosterols and emulsified phytosterols by Sprague-Dawley rats. J Nutr Biochem. (2004) May;15(5):289-95
Gilman TM, Rose JP, Lipka E, Amidon GL, Woltosz WS, Crison J, Bolger MB: GastroPLUSÔ simulated intestinal absorption of drug delivery systems for metoprolol. In: Proceedings of the 1999 Health Sciences Simulation Conference, Anderson JG, Katzper M, Eds., The Society for Computer Simulation International, San Diego, USA pp. 109-114, (1999).
Kaus LC, Gillespie WR, Hussain AS, Amidon GL. The effect of in vivo dissolution, gastric emptying rate and intestinal transit time on the peak concentration and area-under-the-curve of drugs with different gastrointestinal permeabilities. Pharm. Res. ,16, 272 (1999)
Yu LX, Amidon GL. Characterization of small intestinal transit time distribution in humans, Int’l. J. Pharm., 171 157 (1998)
Siersma CA, Kim JS, Lipka E, Chattaraj S, Crison J, Amidon GL. In Vitro-In Vivo Correlation of a Pulsatile Release Delivery System for Pseudoephedrine in the Dog. Pharm. Sci. 1(1): S-495. (1998).
Polli J, Crison J, Amidon GL. Novel Approach to the Analysis of In Vitro-In Vivo Relationships. (1996) J. Pharm. Sci. 85 (7) 753-60.
Lipka, E., Kim, J.S., Siersma, C.A., Crison, J.R, Amidon G.L: Drug Delivery Utilizing a Novel Programmable Oral Release Technology: In Vivo - In Vitro Correlation of Release Times. 23rd Proceed. Intern. Symp. Control. Rel. Bioact. Mater, Kyoto, Japan. p. 575 (1996)
Yu LX, Crison JR, Amidon GL. Compartmental transit and dispersion model analysis of small intestinal transit flow in humans. Int’l. J. Pharm., 140,111 (1996)
Lipka E, Crison JR, Schug BS, Blume HH, Amidon GL: Drug Interactions in the gastrointestinal tract and their impact on drugl absorption and systemic availability: A Mechanistic Review. In: “Mechanisms of Drug Interactions”, ed. D’Arcy, P.F., McElnay, J.C., Welling, PG (Eds) Springer Verlag, Berlin Heidelberg, Ch 2,13 (1996).
Choe, S., Lipka, E., Yu, L., Crison, J.R., Amidon GL: Optimization of Dosage Form Release Parameters Based on Pharmacokinetic and Gastrointestinal Transit Time Considerations. Pharm.Res. 13(9): S-292 (1996).
Lipka E, Lee KD, Langguth P, Spahn-Langguth H, Mutschler E, Amidon GL. Celiprolol double peak occurrence and gastric motility: Nonlinear mixed effects modeling of bioavailability data obtained in dogs. J. Pharm. Biopharm>, 23, 267 (1995)
