We have an active research program covering a wide range of topics related to oral and parenteral drug delivery. Listed below are selected references and patents describing work that has been done in our laboratories and those of our collaborators:
Tubic-Grozdanis M, Hilfinger JM, Amidon GL, Kim JS, Staubach P, Langguth P. Pharmacokinetics of CYP 3A Substrate Simvastatin following Administration of Delayed Versus Immediate Release Oral Dosage Forms. Pharm Res (2008) Jan 24 [Epub ahead of print]
Kish PE., Kim J-S., Roessler B., Campbell S., Hilfinger JM. Bile acid conjugates improve the oral bioavailability of the neuraminidase inhibitor zanamivir. Presented at the 20th ICAR meeting, Rancho Mirage, California, April 30, (2007).
M.P. Desai, J.M. Hilfinger, G.L. Amidon, R.J. Levy and V. Labhasetwar, Immune response with biodegradable nanospheres and alum: studies in rabbits using staphylococcal enterotoxin B-toxoid, J.Microencapsulation, 17, 215 (2000).
Y. Tsume, J.M. Hilfinger, C.A. Siersma, J. Kim and G.L. Amidon, An oral controlled release system for small animals: in vivo testing of the PORT System capsule, 2000 AAPS Annual Meeting, Oct 29-Nov 2, (2000), Indianapolis, IN
Kim JS, Amidon GL. Oral Delivery of Dietary Supplements: Pharmaceutical and Mechanistic Approach. AAPS Dietary Supplements Forum. June 28-30, (2000).
R. Loebenberg, JS Kim, J. Crison and G.L. Amidon, Controlled release of metoprolol: influence of motility and food, Controlled Release Society Meeting, July (2000), Paris, France.
Crison JR, Vieira ML, Kim JS, Siersma C, Amidon GL. Pulsatile, Multiple Dose, Delivery System for Therapeutic Optimization. Controlled Release Society Annual Meeting, Paris, France (2000).
Loebenberg R, Kim JS, Crison JR, Amidon GL, Effect Of Food On The Pulsatile Delivery Of Metoprolol. Pharm. Res. 15: (1999).
Axelrod HR, Kim JS, Longley CB, Lipka E, Amidon, GL, Kakarla R, Hui YW, Weber S, Choe S, Sofia MJ. Intestinal transport of gentamicin with a transphore: A novel, facially amphiphilic, glycosteroid drug transport agent. Pharm. Res 15(12):1876-1881, (1998).
Crison JR, Lipka E, Kim JS, Amidon GL: Lipid-filled hard gelatin capsules as novel drug delivery systems with application to nifedipine. Bulletin Technique Gattefosse, Gattefosse, (1997).
J.M. Hilfinger, E.M. Zimmermann, B.J. Roessler and G.L. Amidon, Oral adenovirus for treatment of inflammatory bowel disease, Proc.Intl.Symp. CRS, 24, 681 (1997).
Crison JR, Siersma PR, Amidon GL. A Novel Programmable Oral Release Technology for Delivering Drugs: Human Feasibility Testing Using Gamma Scintigraphy. Proceed. Int’l Symp. Control. Rel. Bioact. Mater. 23;2 (1996)
Crison JR, Siersma PR, Lipka E, Taylor MD, Amidon GL: Programmable Oral Release Technology, PORT System A Novel Dosage Form for Time and Site Specific Oral Drug Delivery. Proceed. Int’l.. Symp. Control. Rel. Bioact. Mater. 22, p.278 (1995)
Bleske BE, Welage LS, Rose S, Amidon GL, Shea MJ. The effect of dosage release formulations on the pharmacokinetics of propranolol stereoisomers in humans. J. Clin. Pharmacol., 35,374 (1995)
Axelrod, H., Walker, S., Venkatesan, P., Kim, J.S., Sofia, M., Kakarla, R., Chan, T.Y., Amidon, G., Lipka, E., Choe, S., Babu, D., Kahne, S.: Oral Bioavailability of Gentamicin is Increased by Using a Transphore. Pharm. Res. 12(9): S-311 (1995).
Sherman LB, Crison JR, Amidon GL. Optimization of the Water Permeability of Cellulosic Films and Coatings. Proceed. Int’l. Symp. Control. Rel. Bioact. Mater. 21:2 (1994).
H.J. Lee, J.S. Kim, G.L. Amidon, R. Chandrasekharan and N.D. Weiner, Effective delivery of salmon calcitonin employing a surfactant, liposome and a specific absorption site in rats, Abstract, Pharm.Res., S-291 (Nov 1993) Lake Buena Vista, FL.
